PREPRINTS
Lin H, Suzuki K, Smith N, Li X, Nalbach L, Fuentes S, Spigelman AF, Dai XQ, Bautista A, Ferdaoussi M, Aggarwal S, Pepper AR, Roma LP, Ampofo E, Li W, MacDonald PE (2022) Redox sensing by SENP1 augments insulin secretion early after high-fat feeding in mice. bioRxiv, doi.org/10.1101/2022.04.05.487203.
Gosak M, Yan-Do R, Lin H, MacDonald PE, Stozer A (2021) Ca2+ oscillations, waves, and networks in islets from human donors with and without type 2 diabetes. bioRxiv, doi.org/10.1101/2021.12.08.471749.
Arrojo e Drigo R, Erikson G, Tyagi S, Capitanio J, Lyon J, Spigelman AF, Bautista A, Manning Fox JE, Shokhirev M, MacDonald PE, Hetzer MW (2019) Aging of human endocrine pancreatic cell types is heterogeneous and sex-specific. BioRxiv, doi.org/10.1101/729541.
Scavuzzo MA, Chmielowiec J, Teaw J, Yang D, Hill MC, Waksmunski AR, Duraine L, Camunas-Soler J, Dai XQ, King JC, Quake SR, MacDonald PE, Catic A, Borowiak M (2019) NFIA regulates granule recruitment and exocytosis in the adult pancreas. BioRxiv, doi.org/10.1101/2019.12.24.885020.
Ng NHJ, Willems SM....Gloyn AL, Barroso I and the MAGIC EXOME consortium (2019) Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation. BioRxiv, doi.org/10.1101/790618.
Gosak M, Yan-Do R, Lin H, MacDonald PE, Stozer A (2021) Ca2+ oscillations, waves, and networks in islets from human donors with and without type 2 diabetes. bioRxiv, doi.org/10.1101/2021.12.08.471749.
Arrojo e Drigo R, Erikson G, Tyagi S, Capitanio J, Lyon J, Spigelman AF, Bautista A, Manning Fox JE, Shokhirev M, MacDonald PE, Hetzer MW (2019) Aging of human endocrine pancreatic cell types is heterogeneous and sex-specific. BioRxiv, doi.org/10.1101/729541.
Scavuzzo MA, Chmielowiec J, Teaw J, Yang D, Hill MC, Waksmunski AR, Duraine L, Camunas-Soler J, Dai XQ, King JC, Quake SR, MacDonald PE, Catic A, Borowiak M (2019) NFIA regulates granule recruitment and exocytosis in the adult pancreas. BioRxiv, doi.org/10.1101/2019.12.24.885020.
Ng NHJ, Willems SM....Gloyn AL, Barroso I and the MAGIC EXOME consortium (2019) Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation. BioRxiv, doi.org/10.1101/790618.
publications by year (2016-present)
Dafoe TJ, dos Santos T, Spigelman AF, Lyon J, Smith N, Bautista A, MacDonald PE, Manning Fox JE (2022) Impacts of the COVID-19 pandemic on a human research islet program. Islets, in press. (bioRxiv, doi.org/10.1101/2021.12.24.474114).
Marcheva B, Weidemann BJ, Taguchi A, Perelis M, Moynihan Ramsey K, Newman MV, Kobayashi Y, Omura C, Manning Fox JE, Lin H, MacDonald PE, Bass J (2022) P2Y1 purinergic receptor identified as a diabetes target in a small-molecule screen to reverse circadian β-cell failure. eLife, 11:e75132.
Dai XQ, Camunas-Soler J, Briant LJB, Dos Santos T, Spigelman AF, Walker EM, Arrojo E Drigo R, Bautista A, Jones RC, Avrahami D, Lyon J, Nie A, Smith N, Zhang Y, Johnson J, Manning Fox JE, Michelakis ED, Light PE, Kaestner KH, Kim SK, Rorsman P, Stein RW, Quake SR, MacDonald PE. (2022) Heterogenous impairment of α-cell function in type 2 diabetes is linked to cell maturation state. Cell Metabolism, 34 (2), 256-268.e5.
Skovsø S, Panzhinskiy E, Kolic J, Cen HH, Dionne DA, Dai XQ, Sharma RB, Elghazi L, Ellis CE, Faulkner K, Marcil SAM, Overby P, Noursadeghi N, Hutchinson D, Hu X, Li H, Modi H, Wildi JS, Botezelli JD, Noh HL, Suk S, Gablaski B, Bautista A, Kim R, Cras-Méneur C, Flibotte S, Sinha S, Luciani DS, Nislow C, Rideout EJ, Cytrynbaum EN, Kim JK, Bernal-Mizrachi E, Alonso LC, MacDonald PE, Johnson JD (2022) Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance. Nature Communications, 13: 735.
Marquez-Curtis LA, Dai XQ, Hang Y, Lam JY, Lyon J, Manning Fox JE, McGann LE, MacDonald PE, Kim SK, Elliott JAW (2022) Cryopreservation and post-thaw characterization of dissociated human islet cells. PLOS One. doi.org/10.1371/journal.pone.0263005.
Marcheva B, Weidemann BJ, Taguchi A, Perelis M, Moynihan Ramsey K, Newman MV, Kobayashi Y, Omura C, Manning Fox JE, Lin H, MacDonald PE, Bass J (2022) P2Y1 purinergic receptor identified as a diabetes target in a small-molecule screen to reverse circadian β-cell failure. eLife, 11:e75132.
Dai XQ, Camunas-Soler J, Briant LJB, Dos Santos T, Spigelman AF, Walker EM, Arrojo E Drigo R, Bautista A, Jones RC, Avrahami D, Lyon J, Nie A, Smith N, Zhang Y, Johnson J, Manning Fox JE, Michelakis ED, Light PE, Kaestner KH, Kim SK, Rorsman P, Stein RW, Quake SR, MacDonald PE. (2022) Heterogenous impairment of α-cell function in type 2 diabetes is linked to cell maturation state. Cell Metabolism, 34 (2), 256-268.e5.
Skovsø S, Panzhinskiy E, Kolic J, Cen HH, Dionne DA, Dai XQ, Sharma RB, Elghazi L, Ellis CE, Faulkner K, Marcil SAM, Overby P, Noursadeghi N, Hutchinson D, Hu X, Li H, Modi H, Wildi JS, Botezelli JD, Noh HL, Suk S, Gablaski B, Bautista A, Kim R, Cras-Méneur C, Flibotte S, Sinha S, Luciani DS, Nislow C, Rideout EJ, Cytrynbaum EN, Kim JK, Bernal-Mizrachi E, Alonso LC, MacDonald PE, Johnson JD (2022) Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance. Nature Communications, 13: 735.
Marquez-Curtis LA, Dai XQ, Hang Y, Lam JY, Lyon J, Manning Fox JE, McGann LE, MacDonald PE, Kim SK, Elliott JAW (2022) Cryopreservation and post-thaw characterization of dissociated human islet cells. PLOS One. doi.org/10.1371/journal.pone.0263005.
Kim A, Knudsen JG, Madara JC, Benrick A, Hill T, Abdul-Kadir L, Kellard JA, Mellander L, Miranda C, Lin H, James T, Suba K, Spigelman AF, Wu Y, MacDonald PE, Wernstedt Asterholm I, Magnussen T, Christensen M, Vilsboll T, Salem V, Knop FK, Rorsman P, Lowell BB, Briant L (2021) Arginine-vasopressin mediates counter-regulatory glucagon release is diminished in type 1 diabetes. Elife. 2021 Nov 17;10:e72919.
Lin H, Smith N, Spigelman AF, Suzuki K, Ferdaoussi M, Jin Y, Bautista A, Wang YW, Manning Fox JE, Buteau J, MacDonald PE (2021) β-cell SENP1 facilitates responsiveness to incretins and limits oral glucose intolerance in high fat fed mice. Diabetes. 70(11):2626-2638.
Shrestha S, Saunders DC, Walker JT, Camunas-Soler J, Dai XQ, Haliyur R, Aramandla R, Poffenberger G, Prasad N, Bottino R, Stein R, Cartailler JP, Parker SCJ, MacDonald PE, Levy SE, Powers AC, Brissova M (2021) Combinatorial transcription factor profiles predict mature and functional human islet α and β cells. JCI Insight. 6(18):e151621.
Wang S, Flibotte S, Camunas-Soler J, MacDonald PE, Johnson JD (2021) A new hypothesis for type 1 diabetes risk: The at-risk allele at rs3842753 associates with increased beta cell INS mRNA in a meta-analysis of single cell RNA sequencing data. Canadian Journal of Diabetes. doi: 10.1016/j.jcjd.2021.03.007.
Bevacqua RJ, Dai XQ, Lam JY, Gu X, Friedlander MSH, Tellez K, Miguel-Escalada I, Bonàs-Guarch S, Atla G, Zhao W, Kim SH, Dominguez AA, Qi LS, Ferrer J, MacDonald PE, Kim SK (2021) CRISPR-based genome editing in primary human pancreatic islet cells. Nature Communications. 12(1):2397.
Dos Santos T, MacDonald PE (2021) Novel mouse model expands potential human alpha-cell research. Islets. 14:1-4.
Müller JA, Groß R, Conzelmann C, Krüger J, Merle U, Steinhart J, Weil T, Koepke L, Bozzo CP, Read C, Fois G, Eiseler T, Gehrmann J, van Vuuren J, Wessbecher IM, Frick M, Costa IG, Breunig M, Grüner B, Peters L, Schuster M, Liebau S, Seufferlein T, Stenger S, Stenzinger A, MacDonald PE, Kirchhoff F, Sparrer KMJ, Walther P, Lickert H, Barth TFE, Wagner M, Münch J, Heller S, Kleger A (2021) SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas. Nature Metabolism. 3(2):149-165.
Nalbach L, Roma LP, Schmitt BM, Becker V, Körbel C, Wrublewsky S, Pack M, Später T, Metzger W, Menger MM, Frueh FS, Götz C, Lin H, Em Fox J, MacDonald PE, Menger MD, Laschke MW, Ampofo E. (2021) Improvement of islet transplantation by the fusion of islet cells with functional blood vessels. EMBO Molecular Medicine. e12616.
Lin H, Smith N, Spigelman AF, Suzuki K, Ferdaoussi M, Jin Y, Bautista A, Wang YW, Manning Fox JE, Buteau J, MacDonald PE (2021) β-cell SENP1 facilitates responsiveness to incretins and limits oral glucose intolerance in high fat fed mice. Diabetes. 70(11):2626-2638.
Shrestha S, Saunders DC, Walker JT, Camunas-Soler J, Dai XQ, Haliyur R, Aramandla R, Poffenberger G, Prasad N, Bottino R, Stein R, Cartailler JP, Parker SCJ, MacDonald PE, Levy SE, Powers AC, Brissova M (2021) Combinatorial transcription factor profiles predict mature and functional human islet α and β cells. JCI Insight. 6(18):e151621.
Wang S, Flibotte S, Camunas-Soler J, MacDonald PE, Johnson JD (2021) A new hypothesis for type 1 diabetes risk: The at-risk allele at rs3842753 associates with increased beta cell INS mRNA in a meta-analysis of single cell RNA sequencing data. Canadian Journal of Diabetes. doi: 10.1016/j.jcjd.2021.03.007.
Bevacqua RJ, Dai XQ, Lam JY, Gu X, Friedlander MSH, Tellez K, Miguel-Escalada I, Bonàs-Guarch S, Atla G, Zhao W, Kim SH, Dominguez AA, Qi LS, Ferrer J, MacDonald PE, Kim SK (2021) CRISPR-based genome editing in primary human pancreatic islet cells. Nature Communications. 12(1):2397.
Dos Santos T, MacDonald PE (2021) Novel mouse model expands potential human alpha-cell research. Islets. 14:1-4.
Müller JA, Groß R, Conzelmann C, Krüger J, Merle U, Steinhart J, Weil T, Koepke L, Bozzo CP, Read C, Fois G, Eiseler T, Gehrmann J, van Vuuren J, Wessbecher IM, Frick M, Costa IG, Breunig M, Grüner B, Peters L, Schuster M, Liebau S, Seufferlein T, Stenger S, Stenzinger A, MacDonald PE, Kirchhoff F, Sparrer KMJ, Walther P, Lickert H, Barth TFE, Wagner M, Münch J, Heller S, Kleger A (2021) SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas. Nature Metabolism. 3(2):149-165.
Nalbach L, Roma LP, Schmitt BM, Becker V, Körbel C, Wrublewsky S, Pack M, Später T, Metzger W, Menger MM, Frueh FS, Götz C, Lin H, Em Fox J, MacDonald PE, Menger MD, Laschke MW, Ampofo E. (2021) Improvement of islet transplantation by the fusion of islet cells with functional blood vessels. EMBO Molecular Medicine. e12616.
Viñuela A, Varshney A, van de Bunt M, Prasad RB, Asplund O, Bennett A, Boehnke M, Brown AA, Erdos MR, Fadista J, Hansson O, Hatem G, Howald C, Iyengar AK, Johnson P, Krus U, MacDonald PE, Mahajan A, Manning Fox JE, Narisu N, Nylander V, Orchard P, Oskolkov N, Panousis NI, Payne A, Stitzel ML, Vadlamudi S, Welch R, Collins FS, Mohlke KL, Gloyn AL, Scott LJ, Dermitzakis ET, Groop L, Parker SCJ, McCarthy MI. (2020) Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D. Nature Communications. 11(1)4912.
Arrojo e Drigo R, Roy B, MacDonald PE (2020) Molecular and functional profiling of human islets: from heterogeneity to human phenotypes. Diabetologia. 63(10):2095-2101.
Marcheva B, Perelis M, Weidemann BJ, Taguchi A, Lin H, Omura C, Kobayashi Y, Newman MV, Wyatt EJ, McNally EM, Manning Fox JE, Hong H, Shankar A, Wheeler EC, Ramsey KM, MacDonald PE, Yeo GW, Bass J (2020) A Role for Alternative Splicing in Circadian Control of Exocytosis and Glucose Homeostasis. Genes and Development. 34(15-16):1089-1105.
Viloria K, Nasteska D, Briant LJB, Heising S, Larner DP, Fine NHF, Ashford FB, da Silva Xavier G, Ramos MJ, Hasib A, Cuozzo F, Manning Fox JE, MacDonald PE, Akerman I, Lavery GG, Flaxman C, Morgan NG, Richardson SJ, Hewison M, Hodson DJ. (2020) Vitamin-D-binding protein contributes to the maintenance of α cell function and glucagon secretion. Cell Reports. 16;31(11):107761.
Campbell SA, Golec D, Hubert M, Johnson J, Salamon N, Barr A, MacDonald PE, Philippaert K, Light PE (2020) Human islets contain a subpopulation of glucagon-like peptide-1 secreting alpha-cells that is increased in type 2 diabetes. Molecular Metabolism. 39:101014.
Ferdaoussi M, Smith N, Lin H, Bautista A, Spigelman AF, Lyon J, Dai XQ, Manning Fox JE, MacDonald PE (2020) Improved glucose tolerance with DPPIV inhibition requires β‐cell SENP1 amplification of glucose‐stimulated insulin secretion. Physiological Reports. 8(8):e14420.
Camunas-Soler J, Dai XQ, Hang Y, Bautista A, Lyon J, Suzuki K, Kim SK, Quake SR, MacDonald PE (2020) Patch-seq links single-cell transcriptomes to human islet dysfunction in diabetes. Cell Metabolism. 31(5):1017-1031.e4.
Armour SL, Anderson SJ, Richardson SJ, Ding Y, Carey C, Lyon J, Maheshwari RR, Al-Jahdami N, Krasnogor N, Morgan NG, MacDonald PE, Shaw JAM, White MG (2020) Reduced Expression of the Co-regulator TLE1 in Type 2 Diabetes Is Associated with Increased Islet α-Cell Number. Endocrinology. 161(4):bqaa011.
Ackeifi C, Wang P, Karakose E, Manning Fox JE, González BJ, Liu H, Wilson J, Swartz E, Berrouet C, Li Y, Kumar K, MacDonald PE, Sanchez R, Thorens B, DeVita R, Homann D, Egli D, Scott DK, Garcia-Ocaña A, Stewart AF. (2020) GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration. Science Translational Medicine. 12(530). pii: eaaw9996.
Arrojo e Drigo R, Roy B, MacDonald PE (2020) Molecular and functional profiling of human islets: from heterogeneity to human phenotypes. Diabetologia. 63(10):2095-2101.
Marcheva B, Perelis M, Weidemann BJ, Taguchi A, Lin H, Omura C, Kobayashi Y, Newman MV, Wyatt EJ, McNally EM, Manning Fox JE, Hong H, Shankar A, Wheeler EC, Ramsey KM, MacDonald PE, Yeo GW, Bass J (2020) A Role for Alternative Splicing in Circadian Control of Exocytosis and Glucose Homeostasis. Genes and Development. 34(15-16):1089-1105.
Viloria K, Nasteska D, Briant LJB, Heising S, Larner DP, Fine NHF, Ashford FB, da Silva Xavier G, Ramos MJ, Hasib A, Cuozzo F, Manning Fox JE, MacDonald PE, Akerman I, Lavery GG, Flaxman C, Morgan NG, Richardson SJ, Hewison M, Hodson DJ. (2020) Vitamin-D-binding protein contributes to the maintenance of α cell function and glucagon secretion. Cell Reports. 16;31(11):107761.
Campbell SA, Golec D, Hubert M, Johnson J, Salamon N, Barr A, MacDonald PE, Philippaert K, Light PE (2020) Human islets contain a subpopulation of glucagon-like peptide-1 secreting alpha-cells that is increased in type 2 diabetes. Molecular Metabolism. 39:101014.
Ferdaoussi M, Smith N, Lin H, Bautista A, Spigelman AF, Lyon J, Dai XQ, Manning Fox JE, MacDonald PE (2020) Improved glucose tolerance with DPPIV inhibition requires β‐cell SENP1 amplification of glucose‐stimulated insulin secretion. Physiological Reports. 8(8):e14420.
Camunas-Soler J, Dai XQ, Hang Y, Bautista A, Lyon J, Suzuki K, Kim SK, Quake SR, MacDonald PE (2020) Patch-seq links single-cell transcriptomes to human islet dysfunction in diabetes. Cell Metabolism. 31(5):1017-1031.e4.
Armour SL, Anderson SJ, Richardson SJ, Ding Y, Carey C, Lyon J, Maheshwari RR, Al-Jahdami N, Krasnogor N, Morgan NG, MacDonald PE, Shaw JAM, White MG (2020) Reduced Expression of the Co-regulator TLE1 in Type 2 Diabetes Is Associated with Increased Islet α-Cell Number. Endocrinology. 161(4):bqaa011.
Ackeifi C, Wang P, Karakose E, Manning Fox JE, González BJ, Liu H, Wilson J, Swartz E, Berrouet C, Li Y, Kumar K, MacDonald PE, Sanchez R, Thorens B, DeVita R, Homann D, Egli D, Scott DK, Garcia-Ocaña A, Stewart AF. (2020) GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration. Science Translational Medicine. 12(530). pii: eaaw9996.
Khan S, Ferdaoussi M, Bautista A, Bergeron V, Smith N, Poitout V, MacDonald PE (2019) A role for PKD1 in insulin secretion downstream of P2Y1 receptor activation in mouse and human islets. Physiological Reports. 7(19) e14250.
Fu J, Maringa Githaka J, Dai X, Plummer G, Suzuki K, Spigelman AF, Bautista A, Kim R, Greitzer-Antes D, Manning Fox JE, Gaisano HY, MacDonald PE (2019). A glucose-dependent spatial patterning of exocytosis in human β-cells is disrupted in type 2 diabetes. JCI Insight. 5(12)e127896.
Capozzi ME, Svendsen B, Encisco SE, Lewandowski SL, Martin MD, Lin H, Jaffe JL, Coch RW, Haldeman JM, MacDonald PE, Merrins MJ, D'Alessio DA, Campbell JE (2019) β-Cell tone is defined by proglucagon peptides through cyclic AMP signaling. JCI Insight. 4(5):e126742.
Fu J, Maringa Githaka J, Dai X, Plummer G, Suzuki K, Spigelman AF, Bautista A, Kim R, Greitzer-Antes D, Manning Fox JE, Gaisano HY, MacDonald PE (2019). A glucose-dependent spatial patterning of exocytosis in human β-cells is disrupted in type 2 diabetes. JCI Insight. 5(12)e127896.
Capozzi ME, Svendsen B, Encisco SE, Lewandowski SL, Martin MD, Lin H, Jaffe JL, Coch RW, Haldeman JM, MacDonald PE, Merrins MJ, D'Alessio DA, Campbell JE (2019) β-Cell tone is defined by proglucagon peptides through cyclic AMP signaling. JCI Insight. 4(5):e126742.
Thomsen SK, Raimondo A, Hastoy B, Sengupta S, Dai XQ, Bautista A, Censin J, Payne AJ, Umapathysivam MM, Spigelman AF, Barrett A, Groves CJ, Beer NL, Manning Fox JE, McCarthy MI, Clark A, Mahajan A, Rorsman P, MacDonald PE, Gloyn AL (2018) Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells. Nature Genetics, 50(8):1122-1131.
Hart NJ, Aramandla R, Poffenberger G, Fayolle C, Thames AH, Bautista A, Spigelman AF, Babon JAB, DeNicola ME, Dadi PK, Bush WS, Balamurugan AN, Brissova M, Dai C, Prasad N, Bottino R, Jacobson DA, Drumm ML, Kent SC, MacDonald PE, and Powers AC (2018) Cystic fibrosis–related diabetes is caused by islet loss and inflammation. JCI Insight. 2018;3(8):e98240.
Tokarz VL, MacDonald PE, Klip A (2018) The cell biology of systemic insulin function. Journal of Cell Biology. 217(7):2273-2289.
MacDonald PE (2018) A post-translational balancing act: the good and the bad of SUMOylation in pancreatic islets. Diabetologia, 61(4):775-779.
Hart NJ, Aramandla R, Poffenberger G, Fayolle C, Thames AH, Bautista A, Spigelman AF, Babon JAB, DeNicola ME, Dadi PK, Bush WS, Balamurugan AN, Brissova M, Dai C, Prasad N, Bottino R, Jacobson DA, Drumm ML, Kent SC, MacDonald PE, and Powers AC (2018) Cystic fibrosis–related diabetes is caused by islet loss and inflammation. JCI Insight. 2018;3(8):e98240.
Tokarz VL, MacDonald PE, Klip A (2018) The cell biology of systemic insulin function. Journal of Cell Biology. 217(7):2273-2289.
MacDonald PE (2018) A post-translational balancing act: the good and the bad of SUMOylation in pancreatic islets. Diabetologia, 61(4):775-779.
Bozadjieva N, Blandino-Rosano M, Chase J, Dai XQ, Cummings K, Gimeno J, Dean D, Powers AC, Gittes GK, Rüegg MA, Hall MN, MacDonald PE, Bernal-Mizrachi E. (2017) Loss of mTORC1 signalling alters pancreatic alpha cell mass and impairs glucagon secretion. Journal of Clinical Investigation, 127(12):4379-4393.
Fu J, Dai XQ, Plummer G, Suzuki K, Bautista A, Githaka JM, Senior L, Jensen M, Greitzer-Antes D, Manning Fox JE, Gaisano HY, Newgard CB, Touret N, MacDonald PE. (2017) Kv2.1 clustering contributes to insulin exocytosis and rescues human beta-cell dysfunction. Diabetes, 66(7):1890-1900.
Jensen MV, Gooding JR, Ferdaoussi M, Dai XQ, Peterson BS, MacDonald PE, Newgard CB. (2017) Metabolomics applied to islet nutrient sensing mechanisms. Diabetes Obes Metab, 19(Suppl 1): 90-94.
Pepper AR, Pawlick R, Bruni A, Wink J, Rafiei Y, O'Gorman D, Yan-Do R, Gala-Lopez B, Kin T, MacDonald PE, Shapiro AMJ (2017) Transplantation of human pancreatic endoderm cells reverses diabetes post transplantation in a prevascularized subcutaneous site. Stem Cell Reports, 8(6):1689-1700.
Aichler M, Borgmann D, Krumsiek J, Buck A, MacDonald PE, Manning Fox JE, Lyon J, Light PE, Keipert S, Jastroch M, Feuchtinger A, Mueller NS, Sun N, Palmer A, Alexandrov T, Hrabe de Angelis M, Neschen S, Tschöp MH, Walch A. (2017) N-acyl taurines and acylcarnitines cause an imbalance in insulin synthesis and secretion provoking β cell dysfunction in type 2 diabetes. Cell Metabolism, 25(6):1334-1347.
Yan-Do R, MacDonald PE. (2017) Impaired "glycine"-mia in type 2 diabetes and potential mechanisms contributing to glucose homeostasis. Endocrinology, 158(5):1064-1073.
Gordon HM, Majithia N, MacDonald PE, Fox JE, Sharma PR, Byrne FL, Hoehn KL, Evans-Molina C, Langman L, Brayman KL, Nunemaker CS. (2017) STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation. Endocrine, 56(3):528-537.
Ferdaoussi M, Fu J, Dai X, Manning Fox JE, Suzuki K, Smith N, Plummer G, MacDonald PE (2017) SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human β-cells. Scientific Reports, 7(1)248.
Chakravarthy C, Gu X, Enge M, Dai X, Wang Y, Damond N, Downie C, Liu K, Wang J, Xing Y, Chera S, Thorel F, Quake S, Oberholzer J, MacDonald PE, Herrera PL, Kim SK (2017) Converting adult pancreatic islet α cells into β cells by targeting both Dnmt1 and Arx. Cell Metabolism, 25(3)622-634.
Carrat GR, Hu M, Nguyen-Tu MS, Chabosseau P, Gaulton KJ, van de Bunt M, Siddiq A, Falchi M, Thurner M, Canouil M, Pattou F, Leclerc I, Pullen TJ, Cane MC, Prabhala P, Greenwald W, Schulte A, Marchetti P, Ibberson M, MacDonald PE, Manning Fox JE, Gloyn AL, Froguel P, Solimena M, McCarthy MI, Rutter GA (2017) Decreased STARD10 expression is associated with defective insulin secretion in humans and mice. American Journal of Human Genetics, 100(2):238-256.
Ferdaoussi M and MacDonald PE (2017) Toward connecting metabolism to the exocytotic site. Trends in Cell Biology, 27(3):163-171.
Fu J, Dai XQ, Plummer G, Suzuki K, Bautista A, Githaka JM, Senior L, Jensen M, Greitzer-Antes D, Manning Fox JE, Gaisano HY, Newgard CB, Touret N, MacDonald PE. (2017) Kv2.1 clustering contributes to insulin exocytosis and rescues human beta-cell dysfunction. Diabetes, 66(7):1890-1900.
Jensen MV, Gooding JR, Ferdaoussi M, Dai XQ, Peterson BS, MacDonald PE, Newgard CB. (2017) Metabolomics applied to islet nutrient sensing mechanisms. Diabetes Obes Metab, 19(Suppl 1): 90-94.
Pepper AR, Pawlick R, Bruni A, Wink J, Rafiei Y, O'Gorman D, Yan-Do R, Gala-Lopez B, Kin T, MacDonald PE, Shapiro AMJ (2017) Transplantation of human pancreatic endoderm cells reverses diabetes post transplantation in a prevascularized subcutaneous site. Stem Cell Reports, 8(6):1689-1700.
Aichler M, Borgmann D, Krumsiek J, Buck A, MacDonald PE, Manning Fox JE, Lyon J, Light PE, Keipert S, Jastroch M, Feuchtinger A, Mueller NS, Sun N, Palmer A, Alexandrov T, Hrabe de Angelis M, Neschen S, Tschöp MH, Walch A. (2017) N-acyl taurines and acylcarnitines cause an imbalance in insulin synthesis and secretion provoking β cell dysfunction in type 2 diabetes. Cell Metabolism, 25(6):1334-1347.
Yan-Do R, MacDonald PE. (2017) Impaired "glycine"-mia in type 2 diabetes and potential mechanisms contributing to glucose homeostasis. Endocrinology, 158(5):1064-1073.
Gordon HM, Majithia N, MacDonald PE, Fox JE, Sharma PR, Byrne FL, Hoehn KL, Evans-Molina C, Langman L, Brayman KL, Nunemaker CS. (2017) STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation. Endocrine, 56(3):528-537.
Ferdaoussi M, Fu J, Dai X, Manning Fox JE, Suzuki K, Smith N, Plummer G, MacDonald PE (2017) SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human β-cells. Scientific Reports, 7(1)248.
Chakravarthy C, Gu X, Enge M, Dai X, Wang Y, Damond N, Downie C, Liu K, Wang J, Xing Y, Chera S, Thorel F, Quake S, Oberholzer J, MacDonald PE, Herrera PL, Kim SK (2017) Converting adult pancreatic islet α cells into β cells by targeting both Dnmt1 and Arx. Cell Metabolism, 25(3)622-634.
Carrat GR, Hu M, Nguyen-Tu MS, Chabosseau P, Gaulton KJ, van de Bunt M, Siddiq A, Falchi M, Thurner M, Canouil M, Pattou F, Leclerc I, Pullen TJ, Cane MC, Prabhala P, Greenwald W, Schulte A, Marchetti P, Ibberson M, MacDonald PE, Manning Fox JE, Gloyn AL, Froguel P, Solimena M, McCarthy MI, Rutter GA (2017) Decreased STARD10 expression is associated with defective insulin secretion in humans and mice. American Journal of Human Genetics, 100(2):238-256.
Ferdaoussi M and MacDonald PE (2017) Toward connecting metabolism to the exocytotic site. Trends in Cell Biology, 27(3):163-171.
Hamza SM, Sung MM, Gao F, Soltys CL, Smith NP, MacDonald PE, Light PE, Dyck JR (2016) Chronic insulin infusion induces reversible glucose intolerance in lean rats yet ameliorates glucose intolerance in obese rats. Biochim Biophys Acta. S0304-4165(16)30452-4.
Koppe L, Nyam E, Vivot K, Manning Fox JE, Dai XQ, Nguyen BN, Trudel D, Attane C, Moulle VS, MacDonald PE, Ghislain J, Poitout V (2016) Urea impairs beta cell glycolysis and insulin secretion in chronic kidney disease. Journal of Clinical Investigation, 126(9):3598-612.
Kolic J, Manning Fox JE, Chepurny O, Spigelman AF, Ferdaoussi M, Schwede F, Holz GG, MacDonald PE (2016) PI3 kinases p110alpha and PI3K-C2beta negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets. Molecular Metabolism, 5(7):459-71.
Yan-Do R, Duong E, Manning Fox JE, Dai X, Suzuki K, Khan S, Bautista A, Ferdaoussi M, Lyon J, Wu X, Cheley S, MacDonald PE, Braun M (2016) A glycine-insulin autocrine feedback loop enhances insulin secretion from human beta-cells and is impaired in type 2 diabetes. Diabetes, 65(8):2311-21.
Hajmrle C, Smith N, Spigelman AF, Dai X, Senior L, Bautista A, Ferdaoussi M, MacDonald PE (2016) Interleukin-1 singling contributes to acute islet compensation. JCI Insight, 1(4): e86055.
Lyon J, Manning Fox JE, Spigelman AF, Kim R, Smith N, O'Gorman D, Kin T, Shapiro AMJ, Rajotte RV, MacDonald PE (2016) Research-focused isolation of human islets from donors with and without diabetes at the Alberta Diabetes Institute IsletCore. Endocrinology, 157(2): 560-569.
Gala-Lopez BL, Pepper AR, Pawlick RL, O'Gorman D, Kin T, Bruni A, Abualhassan N, Bral M, Bautista A, Manning Fox JE, Young LG, MacDonald PE, Shapiro A (2015) Anti-aging glycopeptide protects human islets against tacrolimus-related injury and facilitates engraftment in mice. Diabetes, 65(2): 451-462.
Campbell JE, Ussher JR, Mulvihill EE, Kolic J, Baggio LL, Cao X, Yu Liu Y, Lamont BJ, Morii T, Streutker CJ, Tamarina N, Philipson LH, Wrana JL, MacDonald PE, Drucker DJ (2015) TCF1 links GIPR signaling to the control of beta cell function and survival. Nature Medicine, 22(1): 84-90.
Koppe L, Nyam E, Vivot K, Manning Fox JE, Dai XQ, Nguyen BN, Trudel D, Attane C, Moulle VS, MacDonald PE, Ghislain J, Poitout V (2016) Urea impairs beta cell glycolysis and insulin secretion in chronic kidney disease. Journal of Clinical Investigation, 126(9):3598-612.
Kolic J, Manning Fox JE, Chepurny O, Spigelman AF, Ferdaoussi M, Schwede F, Holz GG, MacDonald PE (2016) PI3 kinases p110alpha and PI3K-C2beta negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets. Molecular Metabolism, 5(7):459-71.
Yan-Do R, Duong E, Manning Fox JE, Dai X, Suzuki K, Khan S, Bautista A, Ferdaoussi M, Lyon J, Wu X, Cheley S, MacDonald PE, Braun M (2016) A glycine-insulin autocrine feedback loop enhances insulin secretion from human beta-cells and is impaired in type 2 diabetes. Diabetes, 65(8):2311-21.
Hajmrle C, Smith N, Spigelman AF, Dai X, Senior L, Bautista A, Ferdaoussi M, MacDonald PE (2016) Interleukin-1 singling contributes to acute islet compensation. JCI Insight, 1(4): e86055.
Lyon J, Manning Fox JE, Spigelman AF, Kim R, Smith N, O'Gorman D, Kin T, Shapiro AMJ, Rajotte RV, MacDonald PE (2016) Research-focused isolation of human islets from donors with and without diabetes at the Alberta Diabetes Institute IsletCore. Endocrinology, 157(2): 560-569.
Gala-Lopez BL, Pepper AR, Pawlick RL, O'Gorman D, Kin T, Bruni A, Abualhassan N, Bral M, Bautista A, Manning Fox JE, Young LG, MacDonald PE, Shapiro A (2015) Anti-aging glycopeptide protects human islets against tacrolimus-related injury and facilitates engraftment in mice. Diabetes, 65(2): 451-462.
Campbell JE, Ussher JR, Mulvihill EE, Kolic J, Baggio LL, Cao X, Yu Liu Y, Lamont BJ, Morii T, Streutker CJ, Tamarina N, Philipson LH, Wrana JL, MacDonald PE, Drucker DJ (2015) TCF1 links GIPR signaling to the control of beta cell function and survival. Nature Medicine, 22(1): 84-90.
