2019

Camunas-Soler J, Xiaoqing Dai X, Hang Y, Bautista A, Lyon J, Suzuki K, Kim SK, Quake SR, MacDonald PE (2019) Pancreas patch-seq links physiologic dysfunction in diabetes to single-cell transcriptomic phenotypes. BioRxiv Preprint. doi.10.1101/555110.

Fu J, Maringa Githaka J, Dai X, Plummer G, Suzuki K, Spigelman AF, Bautista A, Kim R, Greitzer-Antes D, Manning Fox JE, Gaisano HY, MacDonald PE (2019). A glucose-dependent spatial patterning of exocytosis in human β-cells is disrupted in type 2 diabetes. BioRxiv Preprint. doi.10.1101/534669.

Capozzi ME, Svendsen B, Encisco SE, Lewandowski SL, Martin MD, Lin H, Jaffe JL, Coch RW, Haldeman JM, MacDonald PE, Merrins MJ, D'Alessio DA, Campbell JE (2019) β-Cell tone is defined by proglucagon peptides through cyclic AMP signaling. JCI Insight, doi.10.1172/jci.insight.126742.

2018

Thomsen SK, Raimondo A, Hastoy B, Sengupta S, Dai XQ, Bautista A, Censin J, Payne AJ, Umapathysivam MM, Spigelman AF, Barrett A, Groves CJ, Beer NL, Manning Fox JE, McCarthy MI, Clark A, Mahajan A, Rorsman P, MacDonald PE, Gloyn AL (2018) Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells. Nature Genetics, 50(8):1122-1131.

Hart NJ, Aramandla R, Poffenberger G, Fayolle C, Thames AH, Bautista A, Spigelman AF, Babon JAB, DeNicola ME, Dadi PK, Bush WS, Balamurugan AN, Brissova M, Dai C, Prasad N, Bottino R, Jacobson DA, Drumm ML, Kent SC, MacDonald PE, and Powers AC (2018) Cystic fibrosis–related diabetes is caused by islet loss and inflammation. JCI Insight. 2018;3(8):e98240.

Tokarz VL, MacDonald PE, Klip A (2018) The cell biology of systemic insulin function. Journal of Cell Biology. 217(7):2273-2289.

MacDonald PE (2018) A post-translational balancing act: the good and the bad of SUMOylation in pancreatic islets. Diabetologia, 61(4):775-779.

2017

Bozadjieva N, Blandino-Rosano M, Chase J, Dai XQ, Cummings K, Gimeno J, Dean D, Powers AC, Gittes GK, Rüegg MA, Hall MN, MacDonald PE, Bernal-Mizrachi E. (2017) Loss of mTORC1 signalling alters pancreatic alpha cell mass and impairs glucagon secretion. Journal of Clinical Investigation, 127(12):4379-4393.

Fu J, Dai XQ, Plummer G, Suzuki K, Bautista A, Githaka JM, Senior L, Jensen M, Greitzer-Antes D, Manning Fox JE, Gaisano HY, Newgard CB, Touret N, MacDonald PE. (2017) Kv2.1 clustering contributes to insulin exocytosis and rescues human beta-cell dysfunction. Diabetes, 66(7):1890-1900.
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Jensen MV, Gooding JR, Ferdaoussi M, Dai XQ, Peterson BS, MacDonald PE, Newgard CB. (2017) Metabolomics applied to islet nutrient sensing mechanisms. Diabetes Obes Metab, 19(Suppl 1): 90-94.

Pepper AR, Pawlick R, Bruni A, Wink J, Rafiei Y, O'Gorman D, Yan-Do R, Gala-Lopez B, Kin T, MacDonald PE, Shapiro AMJ (2017) Transplantation of human pancreatic endoderm cells reverses diabetes post transplantation in a prevascularized subcutaneous site. Stem Cell Reports, 8(6):1689-1700.
 
Aichler M, Borgmann D, Krumsiek J, Buck A, MacDonald PE, Manning Fox JE, Lyon J, Light PE, Keipert S, Jastroch M, Feuchtinger A, Mueller NS, Sun N, Palmer A, Alexandrov T, Hrabe de Angelis M, Neschen S, Tschöp MH, Walch A. (2017) N-acyl taurines and acylcarnitines cause an imbalance in insulin synthesis and secretion provoking β cell dysfunction in type 2 diabetes. Cell Metabolism, 25(6):1334-1347.

Yan-Do R, MacDonald PE. (2017) Impaired "glycine"-mia in type 2 diabetes and potential mechanisms contributing to glucose homeostasis. Endocrinology, 158(5):1064-1073.

Gordon HM, Majithia N, MacDonald PE, Fox JE, Sharma PR, Byrne FL, Hoehn KL, Evans-Molina C, Langman L, Brayman KL, Nunemaker CS. (2017) STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation. Endocrine, 56(3):528-537.

Ferdaoussi M, Fu J, Dai X, Manning Fox JE, Suzuki K, Smith N, Plummer G, MacDonald PE (2017) SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human β-cells. Scientific Reports, 7(1)248.

Chakravarthy C, Gu X, Enge M, Dai X, Wang Y, Damond N, Downie C, Liu K, Wang J, Xing Y, Chera S, Thorel F, Quake S, Oberholzer J, MacDonald PE, Herrera PL, Kim SK (2017) Converting adult pancreatic islet α cells into β cells by targeting both Dnmt1 and Arx. Cell Metabolism, 25(3)622-634.

Carrat GR, Hu M, Nguyen-Tu MS, Chabosseau P, Gaulton KJ, van de Bunt M, Siddiq A, Falchi M, Thurner M, Canouil M, Pattou F, Leclerc I, Pullen TJ, Cane MC, Prabhala P, Greenwald W, Schulte A, Marchetti P, Ibberson M, MacDonald PE, Manning Fox JE, Gloyn AL, Froguel P, Solimena M, McCarthy MI, Rutter GA (2017) Decreased STARD10 expression is associated with defective insulin secretion in humans and mice. American Journal of Human Genetics, 100(2):238-256.

Ferdaoussi M and MacDonald PE (2017) Toward connecting metabolism to the exocytotic site. Trends in Cell Biology, 27(3):163-171.

2016

Hamza SM, Sung MM, Gao F, Soltys CL, Smith NP, MacDonald PE, Light PE, Dyck JR (2016) Chronic insulin infusion induces reversible glucose intolerance in lean rats yet ameliorates glucose intolerance in obese rats. Biochim Biophys Acta. S0304-4165(16)30452-4.

Koppe L, Nyam E, Vivot K, Manning Fox JE, Dai XQ, Nguyen BN, Trudel D, Attane C, Moulle VS, MacDonald PE, Ghislain J, Poitout V (2016) Urea impairs beta cell glycolysis and insulin secretion in chronic kidney disease. Journal of Clinical Investigation, 126(9):3598-612.
 
Kolic J, Manning Fox JE, Chepurny O, Spigelman AF, Ferdaoussi M, Schwede F, Holz GG, MacDonald PE (2016) PI3 kinases p110alpha and PI3K-C2beta negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets. Molecular Metabolism, 5(7):459-71.

Yan-Do R, Duong E, Manning Fox JE, Dai X, Suzuki K, Khan S, Bautista A, Ferdaoussi M, Lyon J, Wu X, Cheley S, MacDonald PE, Braun M (2016) A glycine-insulin autocrine feedback loop enhances insulin secretion from human beta-cells and is impaired in type 2 diabetes. Diabetes, 65(8):2311-21.

Hajmrle C, Smith N, Spigelman AF, Dai X, Senior L, Bautista A, Ferdaoussi M, MacDonald PE (2016) Interleukin-1 singling contributes to acute islet compensation. JCI Insight, 1(4): e86055.

Lyon J, Manning Fox JE, Spigelman AF, Kim R, Smith N, O'Gorman D, Kin T, Shapiro AMJ, Rajotte RV, MacDonald PE (2016) Research-focused isolation of human islets from donors with and without diabetes at the Alberta Diabetes Institute IsletCore. Endocrinology, 157(2): 560-569.

Gala-Lopez BL, Pepper AR, Pawlick RL, O'Gorman D, Kin T, Bruni A, Abualhassan N, Bral M, Bautista A, Manning Fox JE, Young LG, MacDonald PE, Shapiro A (2015) Anti-aging glycopeptide protects human islets against tacrolimus-related injury and facilitates engraftment in mice. Diabetes, 65(2): 451-462.

Campbell JE, Ussher JR, Mulvihill EE, Kolic J, Baggio LL, Cao X, Yu Liu Y, Lamont BJ, Morii T, Streutker CJ, Tamarina N, Philipson LH, Wrana JL, MacDonald PE, Drucker DJ (2015) TCF1 links GIPR signaling to the control of beta cell function and survival. Nature Medicine, 22(1): 84-90.

2015

van de Bunt M#, Manning Fox JE#, Dai X, Barrett A, Grey C, Li L, Bennett AJ, Johnson PR, Rajotte RV, Gaulton KJ, Dermitzakis ET, MacDonald PE*, McCarthy MI*, Gloyn AL* (2015) Transcript expression data from human islets links regulatory signals from genome-wide association studies for type 2 diabetes and glycemic traits to their downstream effectors. PLoS Genet. Dec 1;11(12):e1005694. #co-first authors; *co-senior authors

Kolic J and MacDonald PE (2015) cAMP-independent effects of GLP-1 on beta-cells. J Clin Invest, 125(12): 4327-4330.

Gooding JR, Jensen MW, Dai XQ, Wenner, BR, Lu D, Arumugam R, Ferdaoussi M, MacDonald PE*, Newgard CB* (2015) Adenylosuccinate is ain insulin secretagogue derived from glucose-induced purine metabolism. Cell Reports, 13(1): 157-167. *co-senior authors

Ferdaoussi M, Dai X, Jensen MV, Wang R, Peterson BS, Huang C, Ilkayeva O, Smith N, Miller N, Hajmrle C, Spigelman AF, Wright RC, Plummer G, Suzuki K, Mackay JP, van de Bunt M, Gloyn AL, Ryan TE, Norquay LD, Brosnan MJ, Trimmer JK, Rolph TP, Kibbey RG, Manning Fox JE, Colmers WF, Shirihai OS, Neufer PD, Yeh ET*, Newgard CB*, MacDonald PE* (2015) Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional beta-cells. J Clin Invest, 125(10): 3847-3860. *co-senior authors

Schwede F, Chepurny OG, Kaufholz M, Bertinetti D, Leech CA, Cabrera O, Zhu Y, Mei F, Cheng X, Manning Fox JE, MacDonald PE, Genieser HG, Herberg FW, Holz GG (2015) Rp-cAMPS prodrugs reveal the cAMP dependence of first-phase glucose-stimulated insulin secretion. Mol Endocrinol, 29(7): 988-1005.

Manning Fox JE, Lyon J, Dai XQ, Wright RC, Hayward J, van de Bunt M, Kin T, Shapiro AMJ, McCarthy MI, Gloyn AL, Ungrin MD, Lakey JR, Kneteman NM, Warnock GL, Korbutt GS, Rajotte RV, MacDonald PE (2015) Human islet function following 20 years of cryogenic biobanking. Diabetologia, 58(7): 1503-1512.

Fu A, Robitaille K, Faubert B, Reeks C, Dai XQ, Hardy AB, Sankar KS, Ogrel S, Al-Dirbashi AY, Rocheleau JV, Wheeler MB, MacDonald PE, Jones R, Screaton RA (2015) LKB1 couples glucose metabolism to insulin secretion. Diabetologia, 58(7): 1513-1522.

2014

Kushner JA, MacDonald PE, Atkinson MA (2014) Stem cells to insulin secreting cells: Two steps forward and now a time to pause? Cell Stem Cell, 15(5): 535-6.

Kolic J, Spigelman AF, Smith AM, Manning Fox JE, MacDonald PE (2014) Insulin secretion induced by glucose-dependent insulinotropic polypeptide requires PI3 kinase-gamma in rodent and human beta-cells. J Biol Chem, 289(46): 32109-20.

MacDonald PE (2014) Controlling insulin secretion: An exciting TASK. Endocrinology, 155(10): 3729-31.

Khan S, Yan-Do R, Duong E, Wu X, Bautista A, Cheley A, MacDonald PE, Braun M (2014) Autocrine activation of P2Y1 receptors couples Ca2+ influx to Ca2+ release in human pancreatic beta cells. Diabetologia, 57(12): 2535-2545.

Hajmrle C, Ferdaoussi M, Plummer G, Spigelman AF, Lai K, Manning Fox JE, MacDonald PE (2014) SUMOylation protects against IL-1β-induced apoptosis in INS-1 832/13 and human islets. American Journal of Physiology – Endocrinology and Metabolism, 307(8): E664-E673.

Dai XQ, Spigelman AF, Khan S, Braun M, Manning Fox JE, MacDonald PE (2014) SUMO1 enhances cAMP-dependent exocytosis and glucagon secretion from pancreatic a-cells. J Physiol, 592(17): 3715-3726.

Wang L, Luk CT, Schroer SA, Smith AM, Li X, Cai EP, Gaisano HY, MacDonald PE, Hao Z, Mak TW, Woo M (2014) Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions. Diabetologia, 57(9): 1889-98.

Patterson JN, Cousteils K, Lou JW, Manning Fox JE, MacDonald PE, Joseph JW (2014) Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated insulin secretion. J Biol Chem, 289(19): 13335-46.

Gutierrez-Aguilar R, Kim DH, Casimir M, Dai XQ, Pfluger PT, Park J, Haller A, Donelan E, Park J, D'Alessio D, Woods SC, MacDonald PE, Seeley RJ (2014) The role of the transcription factor ETV5 in insulin exocytosis. Diabetologia, 57(2): 383-91.

2013

Yang CYH, Manning Fox JE, Zhang KL, MacDonald PE, Johnson JD (2013) Intraislet SLIT-ROBO signaling is required for beta-cell survival and potentiates insulin secretion. Proc Nat Acad Sci USA, 110(41): 16480-5.

Kolic J, Spigelman AF, Plummer G, Leung E, Hajmrle C, Kin T, Shapiro AMJ, Manning Fox JE, MacDonald PE (2013) Distinct and opposing roles for the type 1A phosphatidylinositol 3-OH kinase catalytic subunits a and b (p110a and p110b) in the regulation of insulin secretion from rodent and human beta cells. Diabetologia, 56(6): 1339-49.

Narang D, Kerr PM, Baserman J, Tam R, Yang W, Searle G, Manning-Fox JE, Paulsen IM, Kozuska JL, MacDonald PE, Light PE, Holt A, Plane F (2013) Triton X-100 inhibits L-type voltage-operated calcium channels. Can J Physiol Pharmacol, 91(4): 316-24.

Manning Fox JE, Seeberger K, Dai XQ, Lyon J, Spigelman AF, Kolic J, Hajmrle C, Joseph JW, Kin T, Shapiro AM, Korbutt G, MacDonald PE (2013) Functional plasticity of the human infant beta-cell exocytotic phenotype. Endocrinology, 154(4): 1392-9.

2012

Gaisano HY, MacDonald PE, Vranic M (2012) Glucagon secretion and signaling in the development of diabetes. Frontiers in Physiology, 3:349.

Kailey B, van de Bunt M, Cheley S, Johnson PR, MacDonald PE, Gloyn AL, Rorsman P, Braun M (2012) SSTR2 is the functionally dominant somatostatin receptor in human pancreatic beta- and alpha-cells. American Journal of Physiology - Endocrinology and Metabolism, 303(9): E1107-16.

Ferdaoussi M, Bergeron V, Zarrouki B, Kolic J, Cantley J, Fielitz J, Olson EN, Prentki M, Biden T, MacDonald PE, Poitout V (2012) G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1. Diabetologia, 55(10): 2682-92.

Vergari E, Plummer G, Dai XQ, MacDonald PE (2012) DeSUMOylation controls insulin exocytosis in response to metabolic signals. Biomolecules, 2(2): 269-81.

Manning Fox JE, Hajmrle C, MacDonald PE (2012) Novel roles of SUMO in pancreatic beta-cells: thinking outside the nucleus. Can J Physiol Pharmacol, 90(6): 765-70.

Cai EP, Casimir M, Schroer SA, Luk CT, Shi SY, Choi D, Dai XQ, Hajmrle C, Spigelman AF, Zhu D, Gaisano HY, MacDonald PE, Woo M (2012) In vivo role of focal adhesion kinase in regulating pancreatic beta-cell mass and function through insulin signaling, actin dynamics, and granule trafficking. Diabetes, 61(7): 1708-18.

Dai XQ, Manning Fox JE, Chikvashvili D, Casimir M, Plummer G, Hajmrle C, Spigelman AF, Kin T, Singer-Lahat D, Kang Y, Shapiro AMJ, Gaisano HY, Lotan I, MacDonald PE (2012) The Kv2.1 channel regulates insulin secretion from rodent and human islets independent of its electrical function. Diabetologia, 55(6): 1709-20.

Hoppa MB, Jones E, Karanauskaite J, Ramracheya R, Braun M, Collins SC, Zhang Q, Clark A, Eliasson L, Genoud C, MacDonald PE, Monteith AG, Barg S, Galvanovskis J, Rorsman P (2012) Multivesicular exocytosis in rat pancreatic beta cells. Diabetologia, 55: 1001-1012.

2011

Kruit JK, Wijesekara N, Manning Fox JE, Dai XQ, Brunham LR, Searle GJ, Morgan GP, Costin AJ, Tang R, Bhattacharjee A, Johnson JD, Light PE, Marsh BJ, MacDonald PE, Verchere CB, Hayden MR (2011) Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules. Diabetes, 60(12):3186-96.

MacDonald PE (2011) Signal integration at the level of ion channel and exocytotic function in pancreatic β-cells. Am J Physiol - Endocrinology and Metabolism, 301(6):E1065-9.

MacDonald PE, Rorsman P (2011) PASK and the control of glucagon secretion (Invited Commentary). Diabetologia, 54(4):719-21.

Dai XQ, Plummer G, Casimir M, Kang Y, Hajmrle C, Gaisano HY, Manning Fox JE, MacDonald PE (2011) SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans. Diabetes, 60(3):838-47.

MacDonald PE (2011) TRP-ing down the path to insulin secretion (Invited Commentary). Diabetes, 60(1):28-9.

2010

Hamming KSC, Soliman D, Webster NJ, Searle GJ, Matemisz LC, Liknes DA, Dai XQ, Pulinilkunnil T, Riedel MJ, Dyck JRB, MacDonald PE, Light PE (2010) Inhibition of beta-cell sodium-calcium exchange enhances glucose-dependent elevations in cytoplasmic calcium and insulin secretion. Diabetes, 59(7):1686-93.

Spigelman A, Dai X, MacDonald PE (2010) Voltage-dependent K+ channels are positive regulators of alpha-cell action potential generation and glucagon secretion. Diabetologia, 53(9):1917-26.

2009

Hardy AB, Manning Fox JE, Giglou PR, Wijesekara N, Bhattacharjee A, Sultan S, Gyulkhandanyan AV, Gaisano HY, MacDonald PE, Wheeler MB (2009) The characterization of ERG K+ channels in alpha and beta cells of mouse and human islets. JBC, 284(44):30441-52.

MacDonald PE (2009) Control of secretory granule access to the plasma membrane by PI3 kinase-gamma. Islets, 1(3):266-268.

Pigeau GM, Kolic J, Ball B, Hoppa M, Wang YW, Ruckle T, Woo M, Manning Fox JE, MacDonald PE (2009) Insulin granule recruitment and exocytosis is dependent on p110gamma. Diabetes, 58(9):2084-92.

Dai XQ, Kolic J, Marchi P, Sipione S, MacDonald PE (2009) SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability. J Cell Sci, 122(6):775-9.

2008

Kränkel N, Katare RG, Siragusa M, Barcelos LS, Campagnolo P, Mangialardi G, Fortunato O, Spinetti G, Tran N, Zacharowski K, Wojakowski W, Mroz I, Herman A, Manning Fox JE, MacDonald PE, Schanstra JP, Bascands JL, Ascione R, Angelini G, Emanueli C, Madeddu P. (2008) Role of kinin B2 receptor signaling in the recruitment of circulating progenitor cells with neovascularization potential. Circ Res, 103(11):1335-43.

Hanna ST, Pigeau GM, Galvanovskis J, Clark A, Rorsman P, MacDonald PE (2008) Kiss-and-run exocytosis and fusion pores of secretory vesicles in human beta-cells. Pflugers Archiv., 457(6):1343-50.

Rorsman P, Salehi SA, Abdulkader F, Braun M, MacDonald PE (2008) KATP-channels and glucose-regulated glucagon secretion. Trends Endocrinol Metab, 19(8):277-84.

Hamming KSC, Riedel MJ, Soliman D, Matemisz LC, Webster NJ, Searle GJ, MacDonald PE, Light PE (2008) Splice variant-dependent regulation of beta-cell sodium-calcium exchange by acyl CoAs. Mol Endocrinol, 22(10):2293-306.

Gyulkhandanyan AV, Lu H, Lee SC, Bhattacharjee A, Wijesekara N, Manning Fox JE, MacDonald PE, Chimienti F, Dai FF, Wheeler MB (2008) Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic beta-cells. J Biol Chem 283(15):10184-97.