How do I sign up to receive human islets?
Please contact Joss by filling out the form to the right.
What documentation is required?
Is a material transfer agreement (MTA) required?
Yes. Once the other documentation is in place, the University of Alberta will coordinate with your tech transfer office to create an MTA.
How much do the islets cost?
Islets are offered on a cost-recovery basis: $0.12 CAD per IEQ for normal donors and $0.18 CAD per IEQ for diabetic donors.
Can I get a discount?
Yes! We also provide the option of signing up for a prepaid subscription of $10,000 CAD for 100,000 IEQ ($0.10 per IEQ).
What information is provided with the islets?
Donor age, sex, body mass index, HbA1c (if available), and any relevant medical history (e.g. diabetes diagnosis or pancreatitis) are provided. Preparation information such as purity, culture time, and photos of dithizone-stained islets are also included.
Can I get additional donor, processing, and islet phenotype information?
Our new web tool, found here, provides much additional information to registered users. In addition to the above info this includes HLA typing, organ processing parameters (e.g. cold ischema time), feedback from other users, and insulin secretion data, and more... We have also initiated a partnership with the Integrated Islet Distribution program (IIDP) Human Islet Phenotyping Program (HIPP). From mid-2019, users will be registered with the HIPP platform to access additional human islet phenotyping data (see iidp.coh.org).
How will I know if islets are available?
An email will be sent out with donor and preparation information. IEQs can be requested by replying directly to that email.
How do you count IEQs?
DTZ-stained islet samples are counted and categorized by size, using a stereomicroscope with a counting reticle. A conversion factor is then applied to correlate islets of different sizes to IEQ (a standard islet equivalent of 100 um diameter). The full protocol is available upon request.
How are the islets shipped?
Islets are shipped with CMRL media in a 50 mL tube at ambient temperature, via FedEx. Recipients in Canada and the United States will receive the islets the next day, while international recipients typically receive them within 48 hours.
What other tissues and samples are available?
We are able to offer paraffin-embedded sections of pancreatic biopsies and isolated islets from normal and diabetic donors; snap-frozen human islets; and viable cryopreserved islets. We can also now offer autologous tissues from pancreas donors including spleen, blood, pancreatic lymph nodes, adipose, acinar, gut).
Pricing for banked islets, pancreas/islet sections, and other tissues are shown here.
What kind of quality assurance do you perform on your islet preparations?
How will you bill me?
Invoices are sent out quarterly, with payment accepted by wire transfer or cheque. For other billing inquiries, please contact Dr. Joss Manning Fox.
How do I report islet preparation quality issues and concerns?
If you suspect that your islet shipment is contaminated, contact Jocelyn Manning Fox (firstname.lastname@example.org) immediately so that IsletCore and other islet recipients can be notified. If your shipment is otherwise unacceptable, you may contact Joss or report the problem through the online Feedback Form. If you are seeking a credit to your subscription, you will be asked to take a digital photograph of the islet prep and submit to IsletCore to substantiate your claim.